2009;145(1):86-88. Raghavenra, H., Diwakr, B. T., Lokesh, B. R., and Naidu, K. A. Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. View abstract. Oper.Dent. Park, C. K., Li, H. Y., Yeon, K. Y., Jung, S. J., Choi, S. Y., Lee, S. J., Lee, S., Park, K., Kim, J. S., and Oh, S. B. Eugenol inhibits sodium currents in dental afferent neurons. 2003;82(10):781-785. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Cloves are used in the cuisine of Asian, African, Mediterranean, and the Near and Middle East countries, lending flavor to meats, curries, and marinades, as well as fruit such as apples, pears, and rhubarb. J Dent 2006;34(10):747-750. 2009;23(4):319-326. View abstract. Rodrigues, T. G., Fernandes, A., Jr., Sousa, J. P., Bastos, J. K., and Sforcin, J. M. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Tooth plaque. Health Benefits of Clove Leaf Essential Oil: 1. View abstract. J Am.Dent.Assoc. A., Reese, S. E., Sima, A. P., and Laskin, D. M. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. 1990;17(6):341-344. It belongs to the Myrtle family. View abstract. View abstract. Oncol Res 2014;21(5):247-59. If you have natural clove leaves, you can simply place the leaf on the painful tooth and leave it there for a few minutes, or, if you have it in liquid form, simply place a drop on the area. View abstract. Jorkjend, L. and Skoglund, L. A. Ibrahim IM, Abdel Kareem IM, Alghobashy MA. We comply with the HONcode standard for trustworthy health information -. Fabio, A., Cermelli, C., Fabio, G., Nicoletti, P., and Quaglio, P. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. View abstract. View abstract. 11th ed. Malson JL, Lee EM, Murty R, et al. Bourgeon Floral de Clou de Girofle, Bouton Floral de Clou de Girofle, Caryophylli Flos, Caryophyllum, Caryophyllus aromaticus, Clavo de Olor, Clous de Girolfe, Clove Flower, Clove Flowerbud, Clove Leaf, Clove Oil, Clove Stem, Cloves, Cloves Bud, Ding Xiang, Eugenia aromatica, Eugenia caryophyllata, Eugenia caryophyllus, Feuille de Clou de Girofle, Fleur de Clou de Girofle, Flores Caryophylli, Flores Caryophyllum, Gewurznelken Nagelein, Girofle, Giroflier, Huile de Clou de Girofle, Kreteks, Lavang, Lavanga, Oil of Clove, Syzygium aromaticum, Tige de Clou de Girofle. Kim, S. S., Oh, O. J., Min, H. Y., Park, E. J., Kim, Y., Park, H. J., Nam, Han Y., and Lee, S. K. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Prostaglandins Leukot.Essent.Fatty Acids 1993;48(5):363-372. View abstract. Nelson, R. L., Thomas, K., Morgan, J., and Jones, A. Not recommended for leave-on products like lotion. Evaluation of the health hazard of clove cigarettes. Clove oil has been used in traditional Indian and Chinese medicine for centuries to relieve tooth pain. Jayashankar, S., Panagoda, G. J., Amaratunga, E. A., Perera, K., and Rajapakse, P. S. A randomised double-blind placebo-controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. Kharfi, M., El, Fekih N., Zayan, F., Mrad, S., and Kamoun, M. R. [Temporary tatooing: black henna or harkous?]. View abstract. Kumar, P., Ansari, S. H., and Ali, J. Herbal remedies for the treatment of periodontal disease--a patent review. View abstract. All rights reserved. Clove Bud Essential Oil generally contains up to 85% Eugenol, a phenol that dramatically contributes to â¦ In general, the level of clove used in foods does not exceed 0.24%; the oil is not used in amounts greater than 0.06%. The clove plant grows in warm climates and is cultivated commercially in Tanzania, Sumatra, the Maluku (Molucca) Islands, and South America. J Indian Soc Periodontol 2014;18(3): 316-20. Contact dermatitis in children. View abstract. The major component of clove taste is imparted by the chemical eugenol. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. View abstract. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. J Dent.Res. View abstract. 2011;69:1571-7. This oil can cause skin irritation. 2005;15(6):437-447. A., Dubois, L., Vink, R., and Horn, J. View abstract. View abstract. They are a common element in spice blends like pumpkin pie spice and speculoos spices. View abstract. Med.Trop.(Mars.) View abstract. Pak.J Pharm.Sci 1990;3(1):1-5. 2. 2005;18(6):347-350. 2012;19(4):625-630. The strongly aromatic clove spice is the dried flower bud; essential oils are obtained from the buds, stems, and leaves. © 2005 - 2019 WebMD LLC. View abstract. View abstract. View abstract. View abstract. 1986;15(2):127-133. No effects on pregnant adult mice were noted.36. 2013;125(2):226-230. They are a popular spice that people use in soups, stews, meats, sauces, and rice dishes. 2005;84(9):848-851. View abstract. Excessive sweating (hyperhidrosis). Clove oil in insecticide form works best when combined with other essential oils, such as peppermint extract or citrus oil. One of the most popular uses of clove leaf oil is that it serves as a good remedy for toothaches and other oral-related problems, thanks to its antibacterial and anodyne properties. Buch, J. G., Dikshit, R. K., and Mansuri, S. M. Effect of certain volatile oils on ejaculated human spermatozoa. Cloves may be used to give aromatic and flavor qualities to hot beverages, often combined with other ingredients such as lemon and sugar. Medically reviewed by Drugs.com. This information should not be used to decide whether or not to take this product. Huss, U., Ringbom, T., Perera, P., Bohlin, L., and Vasange, M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Early research shows that applying a gel containing ground cloves for 5 minutes before being stuck with a needle can reduce needle stick pain. View abstract. J Toxicol.Clin Toxicol. Cisak, E., Wojcik-Fatla, A., Zajac, V., and Dutkiewicz, J. Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases. Islam, S. N., Ferdous, A. J., Ahsan, M., and Faroque, A. Prediabetes. Sign Up to Receive Our Free Coroanvirus Newsletter. 2007;9(6):549-552. It is often substituted for Clove Bud in soap and candle manufacturing. 2004;4(4):27-42. Zanata, R. L., Navarro, M. F., Barbosa, S. H., Lauris, J. R., and Franco, E. B. Clove oil contains a chemical called eugenol. 2004;30(2):195-203. View abstract. Liu H, Schmitz JC, Wei J, et al. J Med Entomol. B., Lee, C. H., Lee, J. K., Park, K., Kim, J. S., and Oh, S. B. Activation of vanilloid receptor 1 (VR1) by eugenol. View abstract. Clove is an herb. View abstract. Pallares, D. E. Link between clove cigarettes and urticaria? J Food Prot. Yakushigaku.Zasshi 2001;36(2):167-170. For a simple clove oil insecticide recipe that make clove oil spray, combine several drops of this oil (or in combination with other essential oils) with a quart of water, and pour the mixture into a spray bottle. 1996;127(11):1582. Uchibayashi, M. [Etymology of clove]. Lee, Y. Y., Hung, S. L., Pai, S. F., Lee, Y. H., and Yang, S. F. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. Clove leaf oil is used in many products like toothpastes, soaps, toiletries, cosmetics, perfumes and candles. Clove oil and eugenol, one of the chemicals it contains, have long been applied to the teeth and gums for toothache, but the U.S. Food and Drug Administration (FDA) has reclassified eugenol, downgrading its effectiveness rating. Washington, DC: American Pharmaceutical Association, 1996. Int J Paediatr.Dent. View abstract. The essential oil of cove leaf comes from the leaf and used to treat skin irritations and many digestive problems. View abstract. Clove Essential Oil Uses. Clove oil contains a compound called eugenol which is known for its antibacterial properties. View abstract. Information regarding safety and efficacy in pregnancy and lactation is lacking. Scientific Name(s): Syzygium aromaticum (L.) Merr. View abstract. Mortazavi, M. and Mesbahi, M. Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth. Clove bud oil produces a strong painkiller-like activity. Hong CH, Hur SK, Oh OJ, et al. 1998;60(2):125-131. Ahmad, N., Alam, M. K., Shehbaz, A., Khan, A., Mannan, A., Hakim, S. R., Bisht, D., and Owais, M. Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis. View abstract. J Cosmet Dermatol 2018;17(6):1084-9. Clove oil cream has been used in the treatment of anal fissures and an extract has exhibited aphrodisiac action in rats; however, there are limited studies supporting clinical applications for clove oil. 2010;68(1):144-148. J Pak Med Assoc 1994;44(5):112-115. View abstract. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with CLOVE. Mosquito repellent. Ghelardini, C., Galeotti, N., Di Cesare, Mannelli L., Mazzanti, G., and Bartolini, A. 2008;47(3):167-173. Clove might slow blood clotting. Ann Agric.Environ.Med. Clove stem and clove leaf essential oils are also available, but essential oil distilled from the buds is generally favored due to its composition and aroma. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. View abstract. View abstract. Ozalp, N., Saroglu, I., and Sonmez, H. Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study. Kim, H. M., Lee, E. H., Hong, S. H., Song, H. J., Shin, M. K., Kim, S. H., and Shin, T. Y. View abstract. View abstract. Physical description and other uses. Hussein E, Ahu A, and Kadir T. Investigation of bacteremia after toothbrushing in orthodontic patients. View abstract. View abstract. Toxicol.Appl.Pharmacol. Available for Android and iOS devices. The FDA now believes there is not enough evidence to rate eugenol as effective for toothache pain. Bhalla, M. and Thami, G. P. Acute urticaria due to dental eugenol. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Clove tea was used to relieve nausea. Common Uses: The leaf of this evergreen, indigenous to Southeast Asia, has a long history as being beneficial for skin irritations and digestion, and to counter bad breath. Common Uses: Clove Leaf Essential Oil is known for its antiseptic and germicidal properties making it an ideal oil for wounds, fungal infections, insect bites and dental care. You should talk with your health care provider for complete information about the risks and benefits of using this product. It grows up to 12 M. Best used for Toothache. Allergy 2008;63(1):137-138. JAMA 6-28-1985;253(24):3551-3552. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Rahim, Z. H. and Khan, H. B. Annales: Economies, Societes, Civilisations 1980;35(3-4):801-815. Although no significant direct cytotoxic effects on the gastric cells or bactericidal effects on H. pylori were found, clove was observed to have strong inhibitory activity on IL-8 at 50 and 100 mcg/mL in H. pylori-infected gastric cells.50 Antiviral activity against herpes simplex and hepatitis C virus has also occurred.3, Mice with induced pneumonia showed a decrease in bacterial colonization when fed clove oil for 15 days.20 Clove oil has been proposed for use in cat and dog ear infections based on in vitro studies.21, In vitro studies have shown antibacterial action against gram-negative anaerobes responsible for acne.22, Sesquiterpenes from cloves reveal anticarcinogenic potential.23 Similarly, eugenol present in clove oil may ameliorate effects of environmental food mutagens.24, Whole cloves were chemoprotective against liver and bone marrow toxicity in mice.25 In mice with induced lung cancer, an oral aqueous preparation of whole clove decreased cell proliferation and increased apoptosis.26, There are no clinical evaluations of clove; however, activity against human cancer cell lines has been demonstrated.3, The use of 1% clove oil cream resulted in significantly greater healing rates than 5% lignocaine in a small study of anal fissures.27. Azuma, Y., Ozasa, N., Ueda, Y., and Takagi, N. Pharmacological studies on the anti-inflammatory action of phenolic compounds. Zheng GQ, Kenney PM, Lam LK. For instance, clove leaf oil contains a marginal amount of Eugenol, more than lesser grades of clove bud oil, but less than higher grades of the bud form. Taking clove oil along with medications that also slow clotting might increase the chances of bruising and bleeding. Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. Pongprayoon, U., Baeckstrom, P., Jacobsson, U., Lindstrom, M., and Bohlin, L. Compounds inhibiting prostaglandin synthesis isolated from Ipomoea pes-caprae. J Dent.Res. Apply this gel over face to cure acne. Alqareer, A., Alyahya, A., and Andersson, L. The effect of clove and benzocaine versus placebo as topical anesthetics. View abstract. 2002;65(10):1545-1560. Where did you or where do you plan to purchase this product? The principal constituents of distilled clove bud oil (60% to 90%) are the phenylpropanoids, including primarily eugenol (4-allyl-2-methoxyphenol) and carvacrol, thymol, and cinnamaldehyde. The tall evergreen plant grows up to 20 m and has leathery leaves. Lane, B. W., Ellenhorn, M. J., Hulbert, T. V., and McCarron, M. Clove oil ingestion in an infant. Yarnell E and Abascal K. Botanical medicines for headache. Int J Paediatr.Dent. Cortés-Rojas DF, de Souza CR, Oliveira WP. Early research shows that taking an extract from clove flower buds right before drinking alcohol improves hangover symptoms in some people. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Quirce, S., Fernandez-Nieto, M., del, Pozo, V, Sastre, B., and Sastre, J. Life Sci. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. J Oral Maxillofac.Surg. Saltzman, B., Sigal, M., Clokie, C., Rukavina, J., Titley, K., and Kulkarni, G. V. Assessment of a novel alternative to conventional formocresol-zinc oxide eugenol pulpotomy for the treatment of pulpally involved human primary teeth: diode laser-mineral trioxide aggregate pulpotomy. J Dent.Res. J Public Health Dent. Musenga, A., Ferranti, A., Saracino, M. A., Fanali, S., and Raggi, M. A. View abstract. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? View abstract. Handbook of Nonprescription Drugs. This information relates to an herbal, vitamin, mineral or other dietary supplement. Contact Dermatitis 1999;41(6):346-347. You can make an acne mask by mixing five drops of clove oil in one fourth cup of aloe vera gel. Fu, Y., Chen, L., Zu, Y., Liu, Z., Liu, X., Liu, Y., Yao, L., and Efferth, T. The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action. Anonymous. Effect of eugenol on macrophage adhesion in vitro to plastic surfaces. For centuries, its benefits are known not only medicinal but also therapeutic. Similarly, it is widely used in â¦ Choi HK, Jung GW, Moon KH, et al. View abstract. 2008;34(2):176-180. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Select one or more newsletters to continue. Contact Dermatitis 1985;12(5):283-284. 1998;14(2):72-74. Lee, M. H., Yeon, K. Y., Park, C. K., Li, H. Y., Fang, Z., Kim, M. S., Choi, S. Y., Lee, S. J., Lee, S., Park, K., Lee, J. H., Kim, J. S., and Oh, S. B. Eugenol inhibits calcium currents in dental afferent neurons. The dark brown buds are 12 to 22 mm in length and have 4 projecting calyx lobes. 1987;66(3):774-777. Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Alternative & Complementary Therapies (England) 2007;13:148-152. Phytother.Res. View abstract. It grows in a tropical climate. View abstract. Shapiro, S., Meier, A., and Guggenheim, B. Clove cigarettes, called "kreteks," generally contain about 60% tobacco and 40% ground cloves.47, 48. 1991;10(4):291-294. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. It may cause irritation to the skin of some individuals and can easily irritate the mucus membranes. Council on Scientific Affairs. J Sep.Sci 2006;29(9):1251-1258. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. Small tears in the lining of the anus (anal fissures). Clove buds yield approximately 15% to 20% of a volatile oil that is responsible for the characteristic aroma and flavor. Anaesth.Intensive Care 2012;40(2):365-366. You need this natural essential oil in your collection. Clove and clove oils are used safely in foods, beverages, and toothpastes. Mishra, R. K. and Singh, S. K. Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. The oil has been used as an expectorant and antiemetic with inconsistent clinical results. Morsy, M. A. and Fouad, A. Natural compounds fight oral pathogens. J Endod. 9-22-2004;52(19):6042-6048. View abstract. (check all that apply). Clove Leaf Essential Oil. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. View abstract. J Ethnopharmacol 2005;96:295-301. Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla-Nakbi, A. Clove essential oil was also found to exhibit anticariogenic and cytotoxic activity against a large number of oral pathogens ().Eugenol and eugenyl acetate are the two active components in clove essential oil that help prevent decalcification or dental erosion ().Clove oil is most effective against microorganisms that cause dental caries ().2. It is evergreen. Robbers JE, Tyler VE. Clove is used for upset stomach and as an expectorant.Expectorants make it easier to cough up phlegm. Clove has historically been used for its antiseptic and analgesic effects. Exp Parasitol 2011;127(4):732-9. 6-6-2003;73(3):337-348. 2-1-2001;170(3):166-171. When derived entirely from the leaf, itâs 77% eugenol. Kim A, Farkas AN, Dewar SB, Abesamis MG. 2007;86(9):898-902. A patient with clove oil intoxication. Phytother.Res. Contact Dermatitis 1996;35:157-62. Lancet 4-16-1983;1(8329):882. View abstract. 2008;46(10):3333-3338. Pharmacol Res 1997;36(6):475-480. Electronic Code of Federal Regulations. Cloves are the flower buds of the clove tree, an evergreen also known as Syzygium aromaticum ().. Found in both whole and ground forms, this â¦ An extract of Syzygium aromaticum represses genes encoding hepatic gluconeogenic enzymes. View abstract. J Ethnopharmacol. A 1% clove oil cream has been used in the treatment of anal fissures.27 Clove oil gel (2:3 vol/vol with glycerin) has been used on induced buccal mucosa pain.13, Information regarding safety and efficacy in pregnancy and lactation is lacking. 2007;21(4):374-377. Soetiarto, F. The relationship between habitual clove cigarette smoking and a specific pattern of dental decay in male bus drivers in Jakarta, Indonesia. View abstract. Int.J Antimicrob.Agents 1999;12(3):257-262. Kim, H. M., Lee, E. H., Kim, C. Y., Chung, J. G., Kim, S. H., Lim, J. P., and Shin, T. Y. Antianaphylactic properties of eugenol. Clove has been reported to have antiplatelet effects; however, case reports are lacking.37, 38, 39 The following are possible based on pharmacologic activity of clove or its ingredients: additive effects of analgesics; anticoagulant medications (including warfarin), aspirin or aspirin-containing products, NSAIDs, or antiplatelet agents (eg, ticlopidine, clopidogrel, dipyridamole). Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., and Apiwathnasorn, C. Comparative repellency of 38 essential oils against mosquito bites. It is also beneficial in eliminating bad breath, and has been used for soap and candle manufacturing for years. 2002;65(11):1517-1521. 2007;33(6):698-702. This product may be unsafe when used before surgery or other medical procedures. Do not use if you're on blood-thinning medications. Did you or will you purchase this product in-store or online? Clove oil cream has been used in the treatment of anal fissures and an extract has exhibited aphrodisiac action in rats; however, there are limited studies supporting clinical applications for clove oil. Contraindications have not been identified. This survey is being conducted by the WebMD marketing sciences department. Dyrbye, B. The antimicrobial activity of essential oils and essential oil components towards oral bacteria. Srivastava, K. C. and Malhotra, N. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. Food Chem.Toxicol. Knaap G. THE GOVERNOR-GENERAL AND THE SULTAN: AN ATTEMPT TO RESTRUCTURE A DIVIDED AMBOINA IN 1638. If it is used in an oil, lotion or cream applied to the skin, the concentration should be well below 1%. 2007;21(6):501-506. Clove may have been combined with other plants or extracts in a specific preparation to treat this condition. 1998;26(2):118-122. Aust.Fam.Physician 1996;25(2):216, 218, 220. This information may not fit your specific health circumstances. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis.J Oral Maxillofac Surg. View abstract. 1980;27(2):85-89. Korean Journal of Orthodontics 2009;39(3):177-184. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. ... uses, and risks of cloves. Clove Bud Essential Oil Uses and Benefits Clove bud is a very diverse essential oil with aromatic properties that relieve nausea , and digestion issues. View abstract. Kothiwale SV, Patwardhan V, Gandhi M, Sohoni R, Kumar A. BMC Complement Altern Med 2019;19(1):99. Cochrane.Database.Syst.Rev. 2009;3(3):221-228. WebMD does not provide medical advice, diagnosis or treatment. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Am J Dent. Janes, S. E., Price, C. S., and Thomas, D. Essential oil poisoning: N-acetylcysteine for eugenol-induced hepatic failure and analysis of a national database. Colorectal Dis. It provides a plethora of benefits for individuals when used around the home and in personal care. Title 21. J Ethnopharmacol. View abstract. To Promote Oral Health. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: effects on growth, viability, adherence and ultrastructure. The appropriate dose of clove depends on several factors such as the user's age, health, and several other conditions. 2005;10(1):193-200. 1-31-2012;139(2):343-349. View abstract. Asian Pac J Trop Biomed 2014;4(2):90-6. It can prove effective in curing acne, reduce swelling and kill infectious bacteria at the same time. Planta Med 1991;57(6):515-518. View abstract. View abstract. 2009;35(2):229-232. Early research shows that applying clove oil or clove oil gel directly to the skin can repel mosquitos for up to 5 hours. Prostaglandins Leukot.Essent.Fatty Acids 2006;74(1):23-27. J Agric.Food Chem. Itching. 2012;2:CD003431. The trees are usually propagated from seeds that are planted in shaded areas. Clove is an herb native to Indonesia in the Asian continent. Stem oil, another source, is up to 87% eugenol. View abstract. What factors influenced or will influence your purchase? Enhanced transdermal delivery of ibuprofen by clove oil has been demonstrated in rabbits.33 Anti-inflammatory activity has been demonstrated in macrophages of mice fed aqueous clove extract.34, 35. View abstract. 2017;55(1):1592-1600. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Park, B. S., Song, Y. S., Yee, S. B., Lee, B. G., Seo, S. Y., Park, Y. C., Kim, J. M., Kim, H. M., and Yoo, Y. H. Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis. For instance, clove leaf oil contains very low levels of eugenol, compared to clove bud oil. Muniz, L. and Mathias, P. The influence of sodium hypochlorite and root canal sealers on post retention in different dentin regions. B. Clove cigarettes. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Jadhav, B. K., Khandelwal, K. R., Ketkar, A. R., and Pisal, S. S. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Other uses not proven with research have included tooth pain , "dry socket" after oral surgery, mouth or throat irritation, cough, upset stomach , vomiting , diarrhea , and other conditions. View abstract. View abstract. To prevent that, use at 1% in wash-off products like soap. A clinical trial in general practice. 2018;67(2):e38-e39. Let us look at them below along with their recommended dosage. View abstract. De Verenigde Oost-Indische Compagnie en de Bevolking van Ambon 1656-1696. Early research shows that applying a clove oil cream to anal tears for 6 weeks improves healing compared to using stool softeners and applying lidocaine cream. Last updated on Jul 3, 2020. Nat.Prod.Res. JAMA 12-23-1988;260(24):3641-3644. Mohan R, Jose S, Mulakkal J, Karpinsky-Semper D, Swick AG, Krishnakumar IM. People use the oils, dried flower buds, leaves, and stems to make medicine. Oral Microbiol.Immunol. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Stomatol.Glas.Srb. There are limited studies to support therapeutic dosing for clove oil. Clove Bud Essential Oil Uses â 9 Best Ways To Use Clove Bud (Including Recipes) Shares. Schattner, P. and Randerson, D. Tiger Balm as a treatment of tension headache. Gen Pharmacol 1996;27:629-33. It also has been used topically as a counterirritant.3. It aids the muscles by reducing pain , and soothes toothaches (as it also serves as a numbing agent). View abstract. Local anaesthetic activity of beta-caryophyllene. Posted November 29, 2012 by Jeff Callahan. View abstract. View abstract. Part 182 -- Substances Generally Recognized As Safe. Knaap G. Kruidnagelen en Christenen. Clove has historically been used for its antiseptic and analgesic effects. J Dent.Res. The antibacterial properties of clove extracts can reduce such skin problems while the anti-inflammatory characteristic lessens the redness and swelling of â¦ Mammen RR, Natinga Mulakal J, Mohanan R, Maliakel B, Illathu Madhavamenon K. Clove bud polyphenols alleviate alterations in inflammation and oxidative stress markers associated with binge drinking: a randomized double-blinded placebo-controlled crossover study. While all types of oil share many of the same clove oil uses, their differences in Eugenol content make some better suited for certain applications than others. View abstract. View abstract. Dwivedi V, Shrivastava R, Hussain S, Ganguly C, Bharadwaj M. Comparative anticancer potential of clove (Syzygium aromaticum)- an Indian spice- against cancer cell lines of various anatomical origin. Prabuseenivasan, S., Jayakumar, M., and Ignacimuthu, S. In vitro antibacterial activity of some plant essential oils. Eur.J Pediatr 2005;164(8):520-522. Effect of Syzygium aromaticum extract on immediate hypersensitivity in rats. Eisen, J. S., Koren, G., Juurlink, D. N., and Ng, V. L. N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure. View abstract. Keep in mind that natural products are not always necessarily safe and dosages can be important. Bonneff M. VU DE KUDUS: L'ISLAM À JAVA. 2007;21(10):989-994. Allergy 2003;58(2):158. A preliminary report. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Uses of Olive Leaf Extract. Phytother.Res. Sanchez-Perez, J. and Garcia-Diez, A. 2008;22(10):1361-1366. Scarparo, R. K., Grecca, F. S., and Fachin, E. V. Analysis of tissue reactions to methacrylate resin-based, epoxy resin-based, and zinc oxide-eugenol endodontic sealers. View abstract. In a toxicological experiment, clove added to the diet of pregnant mice for 2 weeks resulted in increases in cell death. Arora, D. S. and Kaur, J. Antimicrobial activity of spices. Mayaud, L., Carricajo, A., Zhiri, A., and Aubert, G. Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics. Pain 2009;144(1-2):84-94. Clove Leaf oil uses for hair You can use Clove Leaf oil as a natural hair conditioner and to reduce hair fall by massaging into your scalp with a carrier such as Jojoba. It is indigenous to the celebrated Spice Islands, the Moluccas Islands in Indonesia. Clove oil can be a skin and mucous membrane irritant and sensitizer; contact dermatitis has been noted.7, 40 A woman 24 years of age reported permanent local anesthesia and anhidrosis following clove oil spillage onto the facial area.41 Use eugenol, a constituent of clove, with caution in individuals with a history of bleeding, hemostatic disorders, or drug-related hemostatic problems.42, 43, Clove and clove oils are used safely in foods, beverages, and toothpastes. Drug Dev.Ind.Pharm. View abstract. In addition, the bud contains a tannin complex, gum and resin, and a number of glucosides of sterols. The basis for concern regarding health effects. Recent Pat Drug Deliv.Formul. J Nat Prod 1992;55:999-1003. Natural Health 2007;37(9):43-50. J Dent.Res. Clove oil possesses free radical scavenging and iron chelating properties and inhibits lipid peroxidation to a greater extent than eugenol alone.3, 8, 28, 29 Clinical applications are lacking. 2009;69(5):527-528. Saeki, Y., Ito, Y., Shibata, M., Sato, Y., Okuda, K., and Takazoe, I. Antimicrobial action of natural substances on oral bacteria. View abstract. View abstract. Chung, G., Rhee, J. N., Jung, S. J., Kim, J. S., and Oh, S. B. Modulation of CaV2.3 calcium channel currents by eugenol. Blood Coagul.Fibrinolysis 1992;3(5):665-668. View abstract. Clove oil can disinfect acne and prevent acne causing bacteria. Isaacs, G. Permanent local anaesthesia and anhidrosis after clove oil spillage. Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action. 2011;61(2):126-131. A 50% ethanolic extract of clove enhanced the sexual activity of male rats without any adverse or overt toxicological events.30, 31, Clove oil possesses mosquito repellant and other insecticidal activity.3, 32 Eugenol possesses marked antipyretic activity in animals, similar to that of acetaminophen. The spicy scent works well in handmade soap and scrubs. Park, C. K., Kim, K., Jung, S. J., Kim, M. J., Ahn, D. K., Hong, S. D., Kim, J. S., and Oh, S. B. Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. 1986;65(1):53-56. View abstract. Overview Information Clove is a plant grown in parts of Asia and South America. Itinerario 2005;29(1):79-100. J Herb.Pharmacother. Arzneimittelforschung. Hartnoll, G., Moore, D., and Douek, D. Near fatal ingestion of oil of cloves. Saeed, S. A. and Gilani, A. H. Antithrombotic activity of clove oil. Pimples and acne are caused by the accumulation of dirt and harmful bacteria which uses your skin as a breeding ground. 1968;72(12):1155-1158. Benefits. J Oral Sci 2006;48(3):117-123. It should be avoided during pregnancy. Clove cigarette smoking: biochemical, physiological, and subjective effects. Friedman, M., Henika, P. R., and Mandrell, R. E. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. Early research shows that putting a solution containing clove oil gel on the skin can help with severe itching. Non surgical therapy for anal fissure. Clove contains eugenol. View abstract. Segura, J. J. and Jimenez-Rubio, A. Chen, D. C., Lee, Y. Y., Yeh, P. Y., Lin, J. C., Chen, Y. L., and Hung, S. L. Eugenol inhibited the antimicrobial functions of neutrophils. & Perry (Myrtaceae) in animal models. Covington TR, et al. Hangover. View abstract. View abstract. Dissertation Abstracts International Section C 1985;46(4):46-4329c. Thorax 1990;45:235-6. Fotos, P. G., Woolverton, C. J., Van Dyke, K., and Powell, R. L. Effects of eugenol on polymorphonuclear cell migration and chemiluminescence. View abstract. Less commonly, some brands use clove leaf oil or a blend of it. J Dent.Res. View abstract. View abstract. View abstract. View abstract. View abstract. J Endod. View abstract. Srivastava, K. C. Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. The clove tree is an evergeen that grows to about 8 to 12 metres (25 to 40 feet) in height. 2004;14(6):417-424. The oil will promote circulation, which will stimulate hair growth. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. View abstract. Kirsch CM, Yenokida GG, Jensen WA, et al. Clove has a long history of culinary and medicinal use. Toxicity has been observed following ingestion of the oil, but is rare and poorly documented. View abstract. So whichever form you fancy, itâs going to have a lot. Prostaglandins Leukot.Essent.Fatty Acids 1991;42(1):73-81. Yang, B. H., Piao, Z. G., Kim, Y. View abstract. Xing, F., Tan, Y., Yan, G. J., Zhang, J. J., Shi, Z. H., Tan, S. Z., Feng, N. P., and Liu, C. H. Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites. View abstract. Amoxicillin (MIC range, 0.0039 to 0.25 mcg/mL) and metronidazole (MIC range, 64 to 124 mcg/mL) were used as controls.49 Experimentation in H. pylori-infected gastric epithelial cells with 24 medicinal plants indigenous to Pakistan was conducted to evaluate their effect on secretion of interleukin (IL)-8 and generation of reactive oxygen species (ROS) in order to assess anti-inflammatory and cytoprotective effects. Lett Appl Microbiol. However, this study didn't include a control group, so the true effects of clove on blood sugar are not clear. Originating in Indonesia, cloves are dried flower buds from the clove tree. Agbaje, E. O. Gastrointestinal effects of Syzigium aromaticum (L) Merr. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Sosto, F. and Benvenuti, C. Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis. View abstract. Li, H. Y., Park, C. K., Jung, S. J., Choi, S. Y., Lee, S. J., Park, K., Kim, J. S., and Oh, S. B. Eugenol inhibits K+ currents in trigeminal ganglion neurons. Benefits of Clove Bud Oil. Supplement form: The capsules tend to be 500-1000 â¦ Clove (Syzygium aromaticum): a precious spice. Clove and clove oils are used safely in foods, beverages, and toothpastes. Evaluation of topical liposome incorporated clove oil in the treatment of idiopathic palmar hyperhidrosis: Single-blinded placebo-controlled study. J Med Food 2018;21(11):1188-96. Sarrami, N., Pemberton, M. N., Thornhill, M. H., and Theaker, E. D. Adverse reactions associated with the use of eugenol in dentistry. Anti-Aging: Clove oil can help to lessen signs of ageing, wrinkles, and sagging skin. Andersen, K. E., Johansen, J. D., Bruze, M., Frosch, P. J., Goossens, A., Lepoittevin, J. P., Rastogi, S., White, I., and Menne, T. The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. View abstract. The oil also contains approximately 10% acetyleugenol and small quantities of gallic acid, sesquiterpenes, furfural, vanillin, and methyl-n-amyl ketone. Clove Leaf Essential Oil is a very potent oil and should be used with care. Caries Res 1999;33(3):248-250. Use of the oil in dentistry as an analgesic and local antiseptic continues today. Effect of non-eugenol- and eugenol-containing periodontal dressings on the incidence and severity of pain after periodontal soft tissue surgery. Neuron 3-25-2004;41(6):849-857. Lett.Appl.Microbiol. View abstract. Early administration of N-acetylcysteine in the treatment of clove oil ingestion. Clove Leaf Essential oil is very strong in nature and should always be used in a diluted form. Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. Smith-Palmer, A., Stewart, J., and Fyfe, L. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Toothache. Kaya GS, Yapici G, Savas Z, et al. 1989;30(3):129-135. Clove bud essential oil blends well with other spice oils like black pepper (Piper nigrum) and ginger (Zingiber officinale), floral oils like geranium (Pelargonium graveolens), German chamomile (Matricaria recutita), and ylang ylang (Cananga odorata), as well as many others. Revay, E. E., Junnila, A., Xue, R. D., Kline, D. L., Bernier, U. R., Kravchenko, V. D., Qualls, W. A., Ghattas, N., and Muller, G. C. Evaluation of commercial products for personal protection against mosquitoes. Phytother Res 2005;19(4):303-309. A comparative study of antiplaque and antigingivitis effects of herbal mouthrise containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse. View abstract. View abstract. Just mix 2 to 3 drops of pure clove oil with your skin cream and apply gently. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Mortensen, H. [A case of allergic stomatitis due to eugenol]. New York, NY: The Haworth Herbal Press, 1999. BMC.Complement Altern.Med 2006;6:39. View abstract. Guidotti, T. L., Laing, L., and Prakash, U. Toxicity has been observed following ingestion of the oil but is rare and poorly documented.44, 45 There is no documentation of toxicity in the bud, leaf, or stem of the plant.7, In rats, the oral median lethal dose (LD50) of eugenol is 2,680 mg/kg; however, the toxicity of the compound increases almost 200-fold when administered intratracheally (LD50 11 mg/kg).46, Increased toxicity by the pulmonary route has been reported among people who have smoked clove cigarettes. Oil derived from the clove stem contains the highest amount of the compound, which makes it unsuitable for external applications. Phytother.Res. View abstract. Its gland-dotted leaves are small, simple, and opposite. McDougal, R. A., Delano, E. O., Caplan, D., Sigurdsson, A., and Trope, M. Success of an alternative for interim management of irreversible pulpitis. Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., Krisadaphong, P., and Apiwathnasorn, C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . This information is not specific medical advice and does not replace information you receive from your health care provider. Clove has many properties like anti-fungal, anti-inflammatory, boosting energy, improves blood circulations. The stems yield approximately 5% of the oil, and the leaves yield approximately 2%. Asian Pac J Cancer Prev 2011;12(8):1989-93. Chen SJ, Wang MH, Chen IJ. J Cosmet Dermatol 2017;16(4):508-11. Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., and Patapoutian, A. Jiang Q, Wu Y, Zhang H, et al. Postgrad.Med 10-1-1999;106(4):153. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Pediatr Gastroenterol Nutr. The 4 petals above the lobes fold over to form a hood, which hides numerous stamens.1, 2 Synonyms are Eugenia caryophyllata, Eugenia caryophyllus, and Caryophyllus aromaticus. (check all that apply), What factors are most important to you? There are many uses of olive leaf extract. Pharmaceutical Biol. Tandlaegebladet. View abstract. Clove is flower bud of a tree. Dorman HJ, Deans SG. Stojicevic, M., Dordevic, O., Kostic, L., Madanovic, N., and Karanovic, D. [Action of clove oil, eugenol, and zinc-oxide eugenol paste on the dental pulp within "in vitro" conditions]. Other constituents include flavonoids, carbohydrates, lipids, oleanolic acid, rhamnetin, and vitamins.3, 4, 5, 6, 7 Essential oil of the leaf has also been described, similarly containing eugenol, caryophyllene, humulene, and eugenyl acetate.8 Flavonoid triglycosides have been identified in the seeds, and rapid high-performance chromatographic techniques have been developed for determining phenolic acid content.9, 10, Eugenol has been used extensively in dentistry for its anesthetic and antianaerobic bacteria activity.3, 11 The short duration of effect has been used in anesthesia of fish, such as the rainbow trout, channel catfish, and zebra fish.3, 12, Clove oil gel (2:3 vol/vol with glycerin) performed as well as benzocaine gel in an experiment evaluating effect on induced pain in the buccal mucosa.13, In vitro studies demonstrate activity of clove oil against gram-positive and gram-negative bacteria pathogenic to humans, including multiresistant strains.3, 14, 15, 16 Activity against listeria in pasteurized milk has been demonstrated17 as well as antifungal action in vitro against Candida, Aspergillus, and Trichophyton species.15, 16, 18, 19 The leaf extract was found to have a minimal inhibitory concentration (MIC) of 50 mcg/mL against Helicobacter pylori. Apoptosis. Arch.Dis Child 1993;69(3):392-393. Brown, S. A., Biggerstaff, J., and Savidge, G. F. Disseminated intravascular coagulation and hepatocellular necrosis due to clove oil. J Endod. West J Med 1989;151(2):220-228. Int J Oral Maxillofac.Surg. Eugenol is very fragrant and gives allspice and clove their distinctive smell. 1st ed. Early orgasm in men (premature ejaculation). Buy Clove Leaf Essential Oil at BrambleBerry. View abstract. View abstract. View abstract. View abstract. Hum.Exp Toxicol. Mitchell, R. Treatment of fibrinolytic alveolitis by a collagen paste (Formula K). Early research in people with prediabetes shows that taking an extract from clove flower buds seems to lower blood sugar levels before and after a meal. View abstract. Occupational asthma and rhinitis caused by eugenol in a hairdresser. View abstract. 2006;85(10):900-904. Ceylon Med.J 2011;56(1):5-9. View abstract. View abstract. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. View abstract. Urology 2000;55:257-61. Simultaneous determination of aromatic and terpenic constituents of cloves by means of HPLC with diode array detection. J Dent.Res. View abstract. J Ethnopharmacol 2002;83:153-9. 2003;63(4):221-226. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Southeast Asian J Trop.Med Public Health 2004;35(2):325-333. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Elwakeel, H. A., Moneim, H. A., Farid, M., and Gohar, A. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This is only a brief summary of general information about this product. Arch.Dermatol. Endod.Dent.Traumatol. Clove oil is an essential oil thatâs derived from clove trees. Early research shows that using a toothpaste or mouth rinse containing clove and other ingredients helps to reduce plaque on the teeth. Prasad RC, Herzog B, Boone B, et al. B., Rouabhia, M., Mahdouani, K., and Bakhrouf, A. Farmaco 2001;56(5-7):387-389. Nig.Q.J Hosp.Med 2008;18(3):137-141. Romaguera, C., Alomar, A., Camarasa, J. M., Garcia, Bravo B., Garcia, Perez A., Grimalt, F., Guerra, P., Lopez, Gorretcher B., Pascual, A. M., Miranda, A., and . Indian J Med Res 1988;87:361-363. Early research shows that applying clove oil to the palms for 2 weeks helps reduce excessive sweating of the palms. J Drug Target 2005;13(10):555-561. Eugenol is the part of clove that might slow blood clotting. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. Singh, U. P., Singh, D. P., Maurya, S., Maheshwari, R., Singh, M., Dubey, R. S., and Singh, R. B.
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